Efficacy of glutathione arbutin Kojic acid Nicotinamide as cosmetic raw materials

Cosmetic raw materials：Glutathione、

Arbutin、Kojic acid、Nicotinamide、VC ethyl ether

1.1. Anti-aging and enhance resistance: GSH contains active sulfhydryl -SH, which can reduce the H2O2 generated by human cell metabolism to H2O, and clear the free radicals in the human body. Free radicals can damage cell membranes, promote body aging, and induce tumors or arteriosclerosis. GSH has anti-peroxidation effect on human cells, and can also improve the Anti-oxidation ability of the skin and make the skin shiny.
1.2. Fades facial spots
1.3. Help liver detox and anti-allergic
1.4. Block the symptoms of skin darkening caused by ultraviolet rays

2.Arbutin application

The main function is skin lightening and whitening. Formulation: water, cream, ointment, facial mask, etc.
• Arbutin is easy to decompose in an acidic environment, pay attention to the pH control of creams, emulsions and other systems at 5-7;
• Dissolve arbutin in a small amount of water at 50°C and add it at 50°C after the cream is emulsified;
• Add an appropriate amount of antioxidants to the cosmetic system to prevent discoloration;
• After the cream is emulsified, add NaHSO3 and Na2SO3 dissolved in a small amount of water at 50°C (the recommended amount is 0.3-0.4%);
• Adding natural vegetable oils containing oleic acid and linoleic acid can promote the synergistic effect of arbutin;
• Adding 0.8-1.0% Azone in the cosmetic system can promote the absorption of arbutin and prevent the precipitation of arbutin on the skin.
• α-Arbutin can be added up to 7%.
• The concentration of α-arbutin 5% is faster than Vitamin C to lighten the spots, and the light spots are durable and stable, and will not cause skin irritation.

3.Kojic acid effect

Kojic acid properties: It can inhibit the synthesis of tyrosinase and therefore can strongly inhibit the formation of melanin in the skin. Kojic acid at a concentration of 20ug/ml can inhibit 70-80% of a variety of tyrosinase (or polyphenol oxidase PPO). Vitality
Advantages: safe and non-toxic, will not produce leukoplakia sequelae
Application terminal products: lotion, facial mask, lotion, skin cream, etc.
Function: It can effectively treat freckles, age spots, pigmentation, acne, etc., as high-end whitening cosmetics.
Addition amount: The general addition amount in cosmetics is 0.5% to 2.0%.

4.Nicotinamide effect

Niacinamide is a water-soluble substance with solution stability and light stability. In a solution with a pH of 6, the stability is the best.
1. The role of niacinamide: Skin Whitening. When niacinamide is used as a whitening ingredient, when the concentration is 2% to 5%, it proves to have a certain effect on the treatment of chloasma and hyperpigmentation caused by ultraviolet rays. It is said to be more effective in combination with N-acetylglucosamine. Another point of view is that niacinamide also has the function of anti-glycation, which can reduce the yellowness of the glycated protein, which will help the improvement of the skin color of the face of the dish and even the "Yellow Face Po".
2. The effect of nicotinamide: anti-aging. Studies have shown that the use of nicotinamide (content 5%) can reduce wrinkles, erythema, yellowing and stains on aging facial skin. So you don't need to be surprised that Olay's anti-aging line products contain a lot of niacinamide. These effects may also be related to nicotinamide helping to stimulate collagen production
3. The role of nicotinamide: improve the skin barrier function. Local topical nicotinamide can increase the levels of free fatty acids and ceramide in the skin, stimulate the microcirculation of the dermal layer, and prevent skin moisture loss. It can also increase protein synthesis (such as keratin), increase the level of NADPH in cells, and accelerate the differentiation of keratinocytes. In addition, it can alleviate skin irritation caused by surfactants or solvents.
4. Moisturizing The ability to improve skin barrier function means that nicotinamide has moisturizing ability. A small study shows that topical 2% nicotinamide is more effective than petrolatum in reducing skin loss and increasing moisture retention.
5. Oil control and pore reduction External use of nicotinamide (2%) can reduce the production of fatty acids and triglycerides in sebum, and has the effect of controlling oil secretion. It is said to have a synergistic effect with sodium dehydroacetate. The reduction of oil and fat secretion will also make the skin pores look less large.
6. Treatment of acne It is reported that a gel containing 4% niacinamide is as effective as a gel containing 1% clindamycin in the treatment of acne vulgaris (the main topical prescription drug for the treatment of acne).

5.VC ethyl ether

Product performance: As a derivative of vitamin C, the structure is stable, and it overcomes the shortcomings of vitamin C discoloration. At the same time, it has proper fat solubility. It can penetrate the skin stratum corneum and exert the anti-radical and whitening effects of vitamin C. This also makes the formula More flexible. According to research, it has the functions of blocking the formation of melanin, improving skin luster, imparting skin elasticity, and anti-oxidation.
Uses: Used in cosmetics as a whitening agent and Antioxidant (due to its lipophilic and hydrophilic properties, it is very convenient in formulation applications. It is used in gels, essences, lotions, creams and other whitening, anti-aging and other skin care products )
Quality standard: Vitamin C ethyl ether content ≥99%, others meet the requirements of cosmetics standards.

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