Aloe-emodin and tumors

Tumors are cell cancers induced by many factors and have become one of the major diseases endangering human health. Aloe-emodin is an anthraquinone Chinese medicine monomer with a wide range of pharmacological effects. Studies have shown that aloe-emodin exerts anti-tumor effects by blocking the cell cycle, inducing tumor cell apoptosis, and anti-tumor cell metastasis.

Aloe-emodin, abbreviated as AE, also known as aloin, its chemical name is 1,8-Dihydroxy-3-[hydroxymethyl]-anthraquinone (1,8-Dihydroxy-3-[hydroxymethyl]-anthraquinone), and its relative molecular mass is 270 .23.

Although AE has not been used in clinical practice, its anti-tumor effect cannot be ignored. Studies have shown that AE exerts anti-tumor effects by destroying the cell cycle of human acute lymphoblastic leukemia cells, human gastric cancer cell line MKN45, esophageal cancer cell TE1, etc.; by inducing glioma cells, non-small lung cancer H460 cells, cervical cancer cells, etc. Death can achieve the purpose of anti-tumor; it can also play an anti-tumor effect by controlling cell metastasis of prostate cancer cells and melanoma cells. In addition, in vivo, and in vitro angiogenesis experiments have shown that AE inhibits angiogenesis by inhibiting the secretion of urokinase (a serine protease, a key extracellular enzyme in ECM remodeling related to angiogenesis and metastasis), which is anti-AE. The role of tumors is critical. AE has anti-tumor activity against gastric cancer, esophageal cancer, glioma, melanoma, and other cells, indicating its
The anti-tumor effect is very extensive. At the same time, a variety of anti-tumor mechanisms suggest that the anti-tumor effect of AE may not be performed singly. For example, the anti-angiogenesis effect should also play an important role in anti-tumor. It is worthy of more in-depth study to discover anti-tumor drugs. New targets for action. At the same time, it can be seen from existing research that the role of AE in anti-tumor requires in-depth research on the targeting and specificity of tumor cells to increase the therapeutic effect, reduce the damage to normal cells, and be more widely used.