Function Of Andrographis Extract

Andrographis paniculata (scientific name: Andrographis paniculata (Burm. f.) Nees), also known as spring lotus and autumn willow, is happy at first sight, mangrove lotus, bitter grass, golden vanilla, golden ear hook, Indian grass, bitter grass and so on. Annual herb, 4~8 cm long and 1~2.5 cm wide. Medicinal plants have the effects of clearing away heat, detoxifying, reducing inflammation, reducing swelling and relieving pain.

1.Antipyretic effect

Both andrographolide and neoandrographolide have the effect of inhibiting and delaying the increase in body temperature caused by pneumococcus and hemolytic streptococcus, while the latter is not as strong as the former. For rabbits with fever caused by typhoid and paratyphoid vaccine or rats with fever caused by 2,4-dinitrophenol, deoxyandrographolide, andrographolide, neoandrographolide, lactone, and dehydroandrographolide are all It has a certain antipyretic effect, among which dehydroandrographolide has the strongest effect. Intraperitoneal injection of deoxyandrographolide and neoandrographolide in suspension can delay the rise of body temperature and reduce the degree of temperature rise in rabbits with fever caused by simultaneous subcutaneous injection of pneumococcus and hemolytic streptococcus cultures.

2.Anti-Inflammatory effect

Increased permeability of capillaries in the skin or abdominal cavity of mice caused by xylene and acetic acid. Gavage of deoxyandrographolide or dehydroandrographolide can reduce the exudation of capillary walls. Compared with the control, P<0.05 or P< 0.01. Deoxyandrographolide has a significant inhibitory effect on hemorrhagic and necrotic exudation caused by croton oil in rats. Deoxyandrographolide, andrographolide and neoandrographolide at a high dose of 100mg/capsule for 7.5 hours have a significant inhibitory effect on the migration of white blood cells in the rat CMC capsule. The experiment also observed that these four kinds of andrographolide have varying degrees of excitatory effect on the adrenal cortex function of mice, with dehydrated andrographolide being the strongest. Andrographolide and neoandrographolide can inhibit Escherichia coli.

3.Improve immunity

Andrographis paniculata decoction can improve the ability of peripheral blood leukocytes to swallow Staphylococcus aureus in vitro. It has been reported that oral administration of Andrographis paniculata can enhance the delayed skin hypersensitivity reaction of tumor patients and other patients or healthy people to the old tuberculin. Andrographolin injection can also enhance the function of phagocytes. The in vitro test of 3H-thymidine infiltration into lymphocytes showed that andrographis paniculata water-soluble derivative injection has an inhibitory effect on PHA's promotion of 3H-thymidine infiltration. The dehydroandrographolide succinate half ester (DAS) synthesized with andrographolide also inhibited the delayed-type hypersensitivity of mice induced by 2,4-trinitrochlorobenzene. Andrographolide can significantly inhibit the carbon clearance rate in venous blood. Andrographis paniculata preparation, Xindeping (contains esters and ketones) can increase serum lysozyme levels in mice.